Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.

Author(s): Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GSJournal: Nat MedPMID: 29400713 March 2018
Adipocytes possess remarkable adaptive capacity to respond to nutrient excess, fasting or cold exposure, and they are thus an important…

Immune Cell Intolerance for Excess Cholesterol.

Author(s): Widenmaier SB, Hotamisligil GSJournal: ImmunityPMID: 28002726 December 2016
Chronic metabolic challenges have severe consequences on physiological systems. In this issue of Immunity, Ito et al. (2016) show that defects…

Coordinated regulation of protein synthesis and degradation by mTORC1.

Author(s): Zhang Y, Nicholatos J, Dreier JR, Ricoult SJ, Widenmaier SB, Hotamisligil GS, Kwiatkowski DJ, Manning BDJournal: NaturePMID: 25043031 September 2014
Eukaryotic cells coordinately control anabolic and catabolic processes to maintain cell and tissue homeostasis. Mechanistic target of rapamycin complex 1…