Background:
Dr. Arruda began her Postdoctoral Fellowship in the Hotamışlıgil lab in 2010. She was then promoted to a Research Scientist in 2017 before becoming an independent faculty at the University of California, Berkeley in 2022.
Lab Website: Arruda Lab
Publications:
Parlakgül G*, Arruda AP*, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamışlıgil GS. Regulation of liver subcellular architecture controls metabolic homeostasis. Nature. 2022 Mar;603(7902):736-742. doi: 10.1038/s41586-022-04488-5. Epub 2022 Mar 9. PMID: 35264794; PMCID: PMC9014868.*Contributed equally.
Guney E*, Arruda AP*, Parlakgul G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS. Aberrant Ca2+ signaling by IP3Rs in adipocytes links inflammation to metabolic dysregulation in obesity. Sci Signal. 2021 Dec 14;14(713):eabf2059. doi: 10.1126/scisignal.abf2059. Epub 2021 Dec 14. PMID: 34905386; PMCID: PMC10130146.*Contributed equally.
Arruda AP*, Pers BM*, Parlakgul G, Güney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GS. Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity. Elife. 2017 Dec 15;6:e29968. doi: 10.7554/eLife.29968. PMID: 29243589; PMCID: PMC5777820.*Contributed equally.
Arruda AP, Hotamisligil GS. Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes. Cell Metab. 2015 Sep 1;22(3):381-97. doi: 10.1016/j.cmet.2015.06.010. Epub 2015 Jul 16. PMID: 26190652; PMCID: PMC4558313.
Arruda AP*, Pers BM*, Parlakgül G, Güney E, Inouye K, Hotamisligil GS. Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nat Med. 2014 Dec;20(12):1427-35. doi: 10.1038/nm.3735. Epub 2014 Nov 24. PMID: 25419710; PMCID: PMC4412031. *Contributed equally.