Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. Author(s): Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS|Journal: J Clin Invest|PMID: 9389742| December 1997 Cytokines, in particular tumor necrosis factor-alpha (TNF-alpha), have significant effects on energy metabolism and appetite although their mechanisms of action…