Author(s): Tirosh A, Calay ES, Tuncman G, Claiborn KC, Inouye KE, Eguchi K, Alcala M, Rathaus M, Hollander KS, Ron I, Livne R, Heianza Y, Qi L, Shai I, Garg R, Hotamisligil GS|Journal: Sci Transl Med|PMID:31019023| April 2019
The short-chain fatty acid propionate is a potent inhibitor of molds that is widely used as a food preservative and…
Author(s): Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow ME, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS|Journal: Nat Med|PMID:19966778| December 2009
Macrophages show endoplasmic reticulum (ER) stress when exposed to lipotoxic signals associated with atherosclerosis, although the pathophysiological importance and the…
Author(s): Gregor MF, Yang L., Fabbrini E, Mohammed BS, Eagon JC, Hotamisligil GS, Klein S|Journal: Diabetes|PMID:19066313| March 2009
Obesity is associated with insulin resistance and type 2 diabetes, although the mechanisms linking these pathologies remain undetermined. Recent studies…
Author(s): Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS|Journal: Cell|PMID:18805087| September 2008
Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin action and glucose metabolism. Utilizing quantitative lipidomic…
Author(s): Furuhashi M, Fucho R, Gorgun CZ, Tuncman G, Cao H, Hotamisligil GS|Journal: J Clin Invest|PMID:18551191| July 2008
Adipose tissue inflammation is a characteristic of obesity. However, the mechanisms that regulate this inflammatory response and link adipose inflammation…