Publications

Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion.

Author(s): Lee AH, Heidtman K, Hotamisligil GS, Glimcher LH|Journal: Proc Natl Acad Sci U S A|PMID: 21555585| May 2011

As a key regulator of the unfolded protein response, the transcription factor XBP1 activates genes in protein secretory pathways and…

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

Author(s): Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS|Journal: Science|PMID: 15486293| October 2004

Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and…