Publications

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis.

Author(s): Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow ME, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GSJournal: Nat MedPMID: 19966778 December 2009

Macrophages show endoplasmic reticulum (ER) stress when exposed to lipotoxic signals associated with atherosclerosis, although the pathophysiological importance and the…

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

Author(s): Furuhashi M, Tuncman G, Gorgun CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GSJournal: NaturePMID: 17554340 June 2007

Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Studies in aP2-deficient…

Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.

Author(s): Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Brüning JCJournal: Cell MetabPMID: 16581002 April 2006

Inflammatory processes play an important role in the pathogenesis of vascular diseases, and insulin-resistant diabetes mellitus type 2 represents an…

The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis.

Author(s): Makowski L, Hotamisligil GSJournal: Curr Opin LipidolPMID: 16148539 October 2005

The global prevalence of obesity is increasing epidemically. Obesity causes an array of health problems, reduces life expectancy, and costs…

The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities.

Author(s): Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GSJournal: J Biol ChemPMID: 15684432 April 2005

Fatty acid-binding proteins are cytosolic fatty acid chaperones, and the adipocyte isoform, aP2, plays an important role in obesity and…

Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.

Author(s): Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GSJournal: CirculationPMID: 15353487 September 2004

The adipocyte fatty acid-binding protein (FABP) aP2 is expressed by adipocytes and macrophages and modulates insulin resistance, glucose and lipid…

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis.

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.

The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis.

The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities.

Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.

Fatty acid binding proteins–the evolutionary crossroads of inflammatory and metabolic responses.

Role of the fatty acid binding protein mal1 in obesity and insulin resistance.

Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia.

Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.