Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Author(s): Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS|Journal: Mol Cell|PMID: 18342602| March 2008 Mammalian target of rapamycin, mTOR, is a major sensor of nutrient and energy availability in the cell and regulates a…
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Author(s): Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamisligil GS|Journal: Science|PMID: 16931765| August 2006 Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type 2 diabetes. Here, we provide evidence…
