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Publications

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Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

Author(s): Furuhashi M, Tuncman G, Gorgun CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS|Journal: Nature|PMID: 17554340| June 2007
Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Studies in aP2-deficient…

Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.

Author(s): Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS|Journal: Cell Metab|PMID: 16054052| February 2005
Fatty acid binding proteins (FABPs) are cytosolic fatty acid chaperones whose biological role and mechanisms of action are not well…

Role of the fatty acid binding protein mal1 in obesity and insulin resistance.

Author(s): Maeda K, Uysal KT, Makowski L, Gorgun CZ, Atsumi G, Parker RA, Brüning J, Hertzel AV, Bernlohr DA, Hotamisligil GS|Journal: Diabetes|PMID: 12540600| February 2003
The metabolic syndrome is a cluster of metabolic and inflammatory abnormalities including obesity, insulin resistance, type 2 diabetes, hypertension, dyslipidemia,…

Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.

Author(s): Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF|Journal: Nat Med|PMID: 11385507| June 2001
The adipocyte fatty-acid-binding protein, aP2, has an important role in regulating systemic insulin resistance and lipid metabolism. Here we demonstrate…

Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice.

Author(s): Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA, Hotamisligil GS|Journal: Diabetes|PMID: 10512363| October 1999
Recent studies have shown that genetic deficiency of the adipocyte fatty acid-binding protein (aP2) results in minor alterations of plasma…
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