Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

Author(s): Furuhashi M, Tuncman G, Gorgun CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GSJournal: NaturePMID: 17554340 June 2007

Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Studies in aP2-deficient…

Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.

Author(s): Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GSJournal: Cell MetabPMID: 16054052 February 2005

Fatty acid binding proteins (FABPs) are cytosolic fatty acid chaperones whose biological role and mechanisms of action are not well…

Role of the fatty acid binding protein mal1 in obesity and insulin resistance.

Author(s): Maeda K, Uysal KT, Makowski L, Gorgun CZ, Atsumi G, Parker RA, Brüning J, Hertzel AV, Bernlohr DA, Hotamisligil GSJournal: DiabetesPMID: 12540600 February 2003

The metabolic syndrome is a cluster of metabolic and inflammatory abnormalities including obesity, insulin resistance, type 2 diabetes, hypertension, dyslipidemia,…

Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.

Author(s): Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MFJournal: Nat MedPMID: 11385507 June 2001

The adipocyte fatty-acid-binding protein, aP2, has an important role in regulating systemic insulin resistance and lipid metabolism. Here we demonstrate…

Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice.

Author(s): Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA, Hotamisligil GSJournal: DiabetesPMID: 10512363 October 1999

Recent studies have shown that genetic deficiency of the adipocyte fatty acid-binding protein (aP2) results in minor alterations of plasma…