Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

Developmental biology: cell fate in the mammary gland.

Author(s): Tong Q, Hotamisligil GSJournal: NaturePMID: 17301782 February 2007

Regulation of adiponectin in adipocytes upon exposure to HIV-1.

Author(s): Sankalé JL, Tong Q, Hadigan CM, Tan G, Grinspoon SK, Kanki PJ, Hotamisligil GSJournal: HIV MedPMID: 16630040 May 2006

Adipose dysregulation, dyslipidemia, and insulin resistance are hallmarks of HIV-related lipodystrophy. The precise mechanisms behind these disturbances are unknown. In…

The transcription factor GATA2 regulates differentiation of brown adipocytes.

Author(s): Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GSJournal: EMBO RepPMID: 16082385 September 2005

Brown adipose tissue (BAT) is a specialized mammalian tissue and a site of adaptive thermogenesis. Although the metabolic functions of…

Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation.

Author(s): Tong Q, Tsai J, Tan G, Dalgin G, Hotamisligil GSJournal: Mol Cell BiolPMID: 15632071 January 2005

We have previously demonstrated that GATA-2 and GATA-3 are expressed in adipocyte precursors and control the preadipocyte-to-adipocyte transition. Constitutive expression…

GATA transcription factors and fat cell formation.

Author(s): Tong Q, Tsai J, Hotamisligil GSJournal: Drug News PerspectPMID: 14702139 November 2003

GATA transcription factors play important roles in a variety of developmental processes. Recently, we discovered that GATA factors also play…

Regulation of adiponectin in human immunodeficiency virus-infected patients: relationship to body composition and metabolic indices.

Author(s): Tong Q, Sankalé JL, Hadigan CM, Tan G, Rosenberg ES, Kanki PJ, Grinspoon SK, Hotamisligil GSJournal: J Clin Endocrinol MetabPMID: 12679439 April 2003

HIV-related lipodystrophy is characterized by adipose redistribution, dyslipidemia, and insulin resistance. Adiponectin is an adipose-derived peptide thought to act as…

Molecular mechanisms of adipocyte differentiation.

Author(s): Tong Q, Hotamisligil GSJournal: Rev Endocr Metab DisordPMID: 11725721 October 2001

Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists.

Author(s): Way JM, Gorgun CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR Jr, Willson TM, Kliewer SA, Hotamisligil GSJournal: J Biol ChemPMID: 11373275 July 2001

Elevated levels of the hormone resistin, which is secreted by fat cells, are proposed to cause insulin resistance and to…

Function of GATA transcription factors in preadipocyte-adipocyte transition.

Author(s): Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GSJournal: SciencePMID: 11021798 October 2000

Genes that control the early stages of adipogenesis remain largely unknown. Here, we show that murine GATA-2 and GATA-3 are…