Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Author(s): Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS|Journal: Proc Natl Acad Sci U S A|PMID: 16818881| July 2006 The c-Jun N-terminal kinases (JNKs) are key regulators of inflammation and interfere with insulin action in cultured cells and whole…
A central role for JNK in obesity and insulin resistance. Author(s): Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS|Journal: Nature|PMID: 12447443| November 2002 Obesity is closely associated with insulin resistance and establishes the leading risk factor for type 2 diabetes mellitus, yet the…
Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance. Author(s): Xu H, Hirosumi J, Uysal KT, Guler AD, Hotamisligil GS|Journal: Endocrinology|PMID: 11897709| April 2002 Aberrant TNF alpha expression in adipocytes is a molecular mechanism by which insulin action is modulated in adipose tissue. While…
