Publications

Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity.

Author(s): Xu H, Uysal KT, Becherer JD, Arner P, Hotamisligil GS|Journal: Diabetes|PMID: 12031976| June 2002

Tumor necrosis factor-alpha (TNF-alpha) is synthesized as a 26-kDa transmembrane protein (mTNF-alpha), which may present on the cell surface or…

Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance.

Author(s): Xu H, Hirosumi J, Uysal KT, Guler AD, Hotamisligil GS|Journal: Endocrinology|PMID: 11897709| April 2002

Aberrant TNF alpha expression in adipocytes is a molecular mechanism by which insulin action is modulated in adipose tissue. While…

Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha.

Author(s): Chiellini C, Bertacca A, Novelli SE, Gorgun CZ, Ciccarone A, Giordano A, Xu H, Soukas A, Costa M, Gandini D, Dimitri R, Bottone P, Cecchetti P, Pardini E, Perego L, Navalesi R, Folli F, Benzi L, Cinti S, Friedman JM, Hotamisligil GS, Maffei M|Journal: J Cell Physiol|PMID: 11807829| February 2002

Increase in adipose mass results in obesity and modulation of several factors in white adipose tissue (WAT). Two important examples…

Signaling pathways utilized by tumor necrosis factor receptor 1 in adipocytes to suppress differentiation.

Author(s): Xu H, Hotamisligil GS|Journal: FEBS Lett|PMID: 11591379| October 2001

Tumor necrosis factor-alpha (TNFalpha) has profound effects on cultured adipocytes, one of which is the inhibition of terminal differentiation. Previous…

Function of GATA transcription factors in preadipocyte-adipocyte transition.

Author(s): Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GS|Journal: Science|PMID: 11021798| October 2000

Genes that control the early stages of adipogenesis remain largely unknown. Here, we show that murine GATA-2 and GATA-3 are…

Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors.

Author(s): Sethi JK, Xu H, Uysal KT, Wiesbrock SM, Scheja L, Hotamisligil GS|Journal: FEBS Lett|PMID: 10708760| March 2000

Tumour necrosis factor-alpha (TNFalpha) is a multifunctional cytokine that exerts a myriad of biological actions in numerous different tissues including…

Transmembrane tumor necrosis factor (TNF)-alpha inhibits adipocyte differentiation by selectively activating TNF receptor 1.

Author(s): Xu H, Sethi JK, Hotamisligil GS|Journal: J Biol Chem|PMID: 10473584| September 1999

Tumor necrosis factor alpha (TNFalpha) is a potent cytokine with multiple biological activities and exists in two forms as follows:…