Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity.

Author(s): Xu H, Uysal KT, Becherer JD, Arner P, Hotamisligil GSJournal: DiabetesPMID: 12031976 June 2002

Tumor necrosis factor-alpha (TNF-alpha) is synthesized as a 26-kDa transmembrane protein (mTNF-alpha), which may present on the cell surface or…

Fatty acid binding protein expression in different adipose tissue depots from lean and obese individuals.

Author(s): Fisher RM, Eriksson P, Hoffstedt J, Hotamisligil GS, Thörne A, Rydén M, Hamsten A, Arner PJournal: DiabetologiaPMID: 11692175 October 2001

This study investigated the expression of adipose tissue fatty acid binding proteins (FABPs) in subcutaneous and visceral human adipose tissue…

Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance.

Author(s): Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BMJournal: DiabetesPMID: 9032102 March 1997

Previous studies have shown that tumor necrosis factor (TNF)-alpha production from adipose tissue is elevated in rodent and human obesity…

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Author(s): Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BMJournal: J Clin InvestPMID: 7738205 May 1995

Obesity is frequently associated with insulin resistance and abnormal glucose homeostasis. Recent studies in animal models have indicated that TNF-alpha…