SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. Author(s): Emanuelli B, Peraldi P, Filloux C, Chavey C, Freidinger K, Hilton DJ, Hotamisligil GS, Van Obberghen E|Journal: J Biol Chem|PMID: 11604392| December 2001 SOCS (suppressor of cytokine signaling) proteins are inhibitors of cytokine signaling involved in negative feedback loops. We have recently shown…
Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. Author(s): Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM|Journal: J Biol Chem|PMID: 8662983| May 1996 Tumor necrosis factor (TNF)-alpha plays a central role in the state of insulin resistance associated with obesity. It has previously…
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Author(s): Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM|Journal: Science|PMID: 8571133| February 1996 Tumor necrosis factor-alpha (TNF-alpha) is an important mediator of insulin resistance in obesity and diabetes through its ability to decrease…
