Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

Improved glucose and lipid metabolism in genetically obese mice lacking aP2.

Author(s): Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GSJournal: EndocrinologyPMID: 10965911 September 2000

Adipocyte fatty acid-binding protein, aP2, is a member of the intracellular fatty acid binding protein family. Previously, studies have shown…

Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity.

Author(s): Nisoli E, Briscini L, Giordano A, Tonello C, Wiesbrock SM, Uysal KT, Cinti S, Carruba MO, Hotamisligil GSJournal: Proc Natl Acad Sci U S APMID: 10884431 July 2000

Severe quantitative and qualitative brown adipocyte defects are common in obesity. To investigate whether aberrant expression of tumor necrosis factor…

Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors.

Author(s): Sethi JK, Xu H, Uysal KT, Wiesbrock SM, Scheja L, Hotamisligil GSJournal: FEBS LettPMID: 10708760 March 2000

Tumour necrosis factor-alpha (TNFalpha) is a multifunctional cytokine that exerts a myriad of biological actions in numerous different tissues including…

Upregulation of uncoupling protein 2 mRNA in genetic obesity: lack of an essential role for leptin, hyperphagia, increased tissue lipid content, and TNF-alpha.

Author(s): Memon RA, Hotamisligil GS, Wiesbrock SM, Uysal KT, Faggioni R, Moser AH, Feingold KR, Grunfeld CJournal: Biochim Biophys ActaPMID: 10685029 February 2000

Uncoupling protein 2 (UCP2) has been proposed to play a prominent role in the regulation of energy balance. UCP2 mRNA…

Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice.

Author(s): Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA, Hotamisligil GSJournal: DiabetesPMID: 10512363 October 1999

Recent studies have shown that genetic deficiency of the adipocyte fatty acid-binding protein (aP2) results in minor alterations of plasma…

Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1.

Author(s): Samad F, Uysal KT, Wiesbrock SM, Pandey M, Hotamisligil GS, Loskutoff DJJournal: Proc Natl Acad Sci U S APMID: 10359811 June 1999

Obesity is associated with a cluster of abnormalities, including hypertension, insulin resistance, hyperinsulinemia, and elevated levels of both plasminogen activator…

Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity.

Author(s): Uysal KT, Wiesbrock SM, Hotamisligil GSJournal: EndocrinologyPMID: 9832419 December 1998

Although obesity has become the most common metabolic disorder in the developed world and is highly associated with insulin resistance…

Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes.

Author(s): Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GSJournal: J Clin InvestPMID: 9389742 December 1997

Cytokines, in particular tumor necrosis factor-alpha (TNF-alpha), have significant effects on energy metabolism and appetite although their mechanisms of action…

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function.

Author(s): Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GSJournal: NaturePMID: 9335502 October 1997

Obesity is highly associated with insulin resistance and is the biggest risk factor for non-insulin-dependent diabetes mellitus. The molecular basis…