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Publications

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Improved glucose and lipid metabolism in genetically obese mice lacking aP2.

Author(s): Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GS|Journal: Endocrinology|PMID: 10965911| September 2000
Adipocyte fatty acid-binding protein, aP2, is a member of the intracellular fatty acid binding protein family. Previously, studies have shown…

Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity.

Author(s): Nisoli E, Briscini L, Giordano A, Tonello C, Wiesbrock SM, Uysal KT, Cinti S, Carruba MO, Hotamisligil GS|Journal: Proc Natl Acad Sci U S A|PMID: 10884431| July 2000
Severe quantitative and qualitative brown adipocyte defects are common in obesity. To investigate whether aberrant expression of tumor necrosis factor…

Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors.

Author(s): Sethi JK, Xu H, Uysal KT, Wiesbrock SM, Scheja L, Hotamisligil GS|Journal: FEBS Lett|PMID: 10708760| March 2000
Tumour necrosis factor-alpha (TNFalpha) is a multifunctional cytokine that exerts a myriad of biological actions in numerous different tissues including…

Upregulation of uncoupling protein 2 mRNA in genetic obesity: lack of an essential role for leptin, hyperphagia, increased tissue lipid content, and TNF-alpha.

Author(s): Memon RA, Hotamisligil GS, Wiesbrock SM, Uysal KT, Faggioni R, Moser AH, Feingold KR, Grunfeld C|Journal: Biochim Biophys Acta|PMID: 10685029| February 2000
Uncoupling protein 2 (UCP2) has been proposed to play a prominent role in the regulation of energy balance. UCP2 mRNA…

Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice.

Author(s): Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA, Hotamisligil GS|Journal: Diabetes|PMID: 10512363| October 1999
Recent studies have shown that genetic deficiency of the adipocyte fatty acid-binding protein (aP2) results in minor alterations of plasma…

Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1.

Author(s): Samad F, Uysal KT, Wiesbrock SM, Pandey M, Hotamisligil GS, Loskutoff DJ|Journal: Proc Natl Acad Sci U S A|PMID: 10359811| June 1999
Obesity is associated with a cluster of abnormalities, including hypertension, insulin resistance, hyperinsulinemia, and elevated levels of both plasminogen activator…

Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity.

Author(s): Uysal KT, Wiesbrock SM, Hotamisligil GS|Journal: Endocrinology|PMID: 9832419| December 1998
Although obesity has become the most common metabolic disorder in the developed world and is highly associated with insulin resistance…

Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes.

Author(s): Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS|Journal: J Clin Invest|PMID: 9389742| December 1997
Cytokines, in particular tumor necrosis factor-alpha (TNF-alpha), have significant effects on energy metabolism and appetite although their mechanisms of action…

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function.

Author(s): Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS|Journal: Nature|PMID: 9335502| October 1997
Obesity is highly associated with insulin resistance and is the biggest risk factor for non-insulin-dependent diabetes mellitus. The molecular basis…
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