Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance.

Author(s): Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BMJournal: DiabetesPMID: 9032102 March 1997

Previous studies have shown that tumor necrosis factor (TNF)-alpha production from adipose tissue is elevated in rodent and human obesity…

Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.

Author(s): Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BMJournal: SciencePMID: 8910278 November 1996

Fatty acid binding proteins (FABPs) are small cytoplasmic proteins that are expressed in a highly tissue-specific manner and bind to…

Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase.

Author(s): Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BMJournal: J Biol ChemPMID: 8662983 May 1996

Tumor necrosis factor (TNF)-alpha plays a central role in the state of insulin resistance associated with obesity. It has previously…

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance.

Author(s): Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BMJournal: SciencePMID: 8571133 February 1996

Tumor necrosis factor-alpha (TNF-alpha) is an important mediator of insulin resistance in obesity and diabetes through its ability to decrease…

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Author(s): Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BMJournal: J Clin InvestPMID: 7738205 May 1995

Obesity is frequently associated with insulin resistance and abnormal glucose homeostasis. Recent studies in animal models have indicated that TNF-alpha…

Tumor necrosis factor alpha: a key component of the obesity-diabetes link.

Author(s): Hotamisligil GS, Spiegelman BMJournal: DiabetesPMID: 7926300 November 1994

Recent data have suggested a key role for tumor necrosis factor (TNF)-alpha in the insulin resistance of obesity and non-insulin-dependent…

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

Author(s): Hotamisligil GS, Budavari A, Murray D, Spiegelman BMJournal: J Clin InvestPMID: 7523453 October 1994

Insulin resistance is an important metabolic abnormality often associated with infections, cancer, obesity, and especially non-insulin-dependent diabetes mellitus (NIDDM). We…

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

Author(s): Hotamisligil GS, Murray DL, Choy LN, Spiegelman BMJournal: Proc Natl Acad Sci U S APMID: 8197147 May 1994

Insulin resistance is a common problem associated with infections and cancer and, most importantly, is the central component of non-insulin-dependent…

Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance.

Author(s): Hofmann C, Lorenz K, Braithwaite SS, Colca JR, Palazuk BJ, Hotamisligil GS, Spiegelman BMJournal: EndocrinologyPMID: 8275942 January 1994

As obesity is a major risk factor for noninsulin-dependent diabetes mellitus, adipose tissue may generate a mediator that influences the…

Through thick and thin: wasting, obesity, and TNF alpha.

Author(s): Spiegelman BM, Hotamisligil GSJournal: CellPMID: 8500160 May 1993