Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. Author(s): Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM|Journal: J Biol Chem|PMID: 8662983| May 1996 Tumor necrosis factor (TNF)-alpha plays a central role in the state of insulin resistance associated with obesity. It has previously…