Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Author(s): Hotamisligil GS, Shargill NS, Spiegelman BM|Journal: Science|PMID: 7678183| January 1993 Tumor necrosis factor-alpha (TNF-alpha) has been shown to have certain catabolic effects on fat cells and whole animals. An induction…