Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism.

Author(s): Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GSJournal: Cell MetabPMID: 33340456 December 2020

Endoplasmic reticulum stress (ERS) has a pathophysiological role in obesity-associated insulin resistance. Yet, the coordinated tissue response to ERS remains…

METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.

Author(s): Yang L., Calay ES, Fan J, Arduini A, Kunz RC, Gygi SP, Yalcin A, Fu S, Hotamisligil GSJournal: SciencePMID: 26228140 July 2015

The association between inflammation and endoplasmic reticulum (ER) stress has been observed in many diseases. However, if and how chronic…

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity.

Author(s): Fu S, Yalcin A, Lee GY, Li P, Fan J, Arruda AP, Pers BM, Yilmaz M, Eguchi K, Hotamisligil GSJournal: Sci Transl MedPMID: 26084805 June 2015

The endoplasmic reticulum (ER) plays a critical role in protein, lipid, and glucose metabolism as well as cellular calcium signaling…

Impact of ER protein homeostasis on metabolism.

Author(s): Yalcin A, Hotamisligil GSJournal: DiabetesPMID: 23431011 March 2013

Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis.

Author(s): ten Freyhaus H, Calay ES, Yalcin A, Vallerie SN, Yang L., Calay ZZ, Saatcioglu F, Hotamisligil GSJournal: Cell MetabPMID: 22704678 July 2012

The six-transmembrane protein Stamp2 plays an important role in metabolically triggered inflammation and insulin action. We report that Stamp2 is…

Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress.

Author(s): Oh RS, Pan WC, Yalcin A, Zhang H, Guilarte TR, Hotamisligil GS, Christiani DC, Lu QJournal: J Biol ChemPMID: 22215663 February 2012

Exposure to the toxic metalloid arsenic is associated with diabetes and cancer and causes proteotoxicity and endoplasmic reticulum (ER) stress…