Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

Adipocytes promote interleukin-18 binding to its receptors during abdominal aortic aneurysm formation in mice.

Author(s): Liu CL, Ren J, Wang Y, Zhang X, Sukhova GK, Liao M, Santos M, Luo S, Yang D, Xia M, Inouye K, Hotamisligil GS, Lu G, Upchurch GR, Libby P, Guo J, Zhang J, Shi GPJournal: Eur Heart JPMID: 31821481 July 2020

Obesity is a risk factor of abdominal aortic aneurysm (AAA). Inflammatory cytokine interleukin-18 (IL18) has two receptors: IL18 receptor (IL18r)…

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice.

Author(s): Liu J, Divoux A, Sun J, Zhang J, Clement K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GPJournal: Nat MedPMID: 19633655 August 2009

Although mast cell functions have classically been related to allergic responses, recent studies indicate that these cells contribute to other…