Author(s): Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamisligil GS|Journal: Nature|PMID:35264794| March 2022
Cells display complex intracellular organization by compartmentalization of metabolic processes into organelles, yet the resolution of these structures in the…
Author(s): Güney E, Arruda AP, Parlakgül G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS|Journal: Sci Signal|PMID:34905386| December 2021
Chronic metabolic inflammation is a key feature of obesity, insulin resistance, and diabetes. Here, we showed that altered regulation of…
Author(s): Liu CL, Ren J, Wang Y, Zhang X, Sukhova GK, Liao M, Santos M, Luo S, Yang D, Xia M, Inouye K, Hotamisligil GS, Lu G, Upchurch GR, Libby P, Guo J, Zhang J, Shi GP|Journal: Eur Heart J|PMID:31821481| July 2020
Obesity is a risk factor of abdominal aortic aneurysm (AAA). Inflammatory cytokine interleukin-18 (IL18) has two receptors: IL18 receptor (IL18r)…
Author(s): Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH|Journal: Nature|PMID:24153306| October 2013
Food intake increases the activity of hepatic de novo lipogenesis, which mediates the conversion of glucose to fats for storage…
Author(s): Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS|Journal: Cell Metab|PMID:23663740| May 2013
Proper control of hepatic glucose production is central to whole-body glucose homeostasis, and its disruption plays a major role in…
Author(s): Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ|Journal: Nature|PMID:22801494| August 2012
The inflammasome regulates the release of caspase activation-dependent cytokines, including interleukin (IL)-1β, IL-18 and high-mobility group box 1 (HMGB1). By…
