Author(s): Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamisligil GS|Journal: Nature|PMID:35264794| March 2022
Cells display complex intracellular organization by compartmentalization of metabolic processes into organelles, yet the resolution of these structures in the…
Author(s): Güney E, Arruda AP, Parlakgül G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS|Journal: Sci Signal|PMID:34905386| December 2021
Chronic metabolic inflammation is a key feature of obesity, insulin resistance, and diabetes. Here, we showed that altered regulation of…
Author(s): Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GS|Journal: Cell Metab|PMID:33340456| December 2020
Endoplasmic reticulum stress (ERS) has a pathophysiological role in obesity-associated insulin resistance. Yet, the coordinated tissue response to ERS remains…
Author(s): Arruda AP, Pers BM, Parlakgül G, Güney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GS|Journal: Elife|PMID:29243589| December 2017
Defective Ca handling is a key mechanism underlying hepatic endoplasmic reticulum (ER) dysfunction in obesity. ER Ca level is in…
Author(s): Widenmaier SB, Snyder NA, Nguyen TB, Arduini A, Lee GY, Arruda AP, Saksi J, Bartelt A, Hotamisligil GS|Journal: Cell|PMID:29149604| November 2017
Cholesterol is a critical nutrient requiring tight constraint in the endoplasmic reticulum (ER) due to its uniquely challenging biophysical properties. While…
Author(s): Arruda AP, Hotamisligil GS|Journal: Cell Metab|PMID:26190652| September 2015
A number of chronic metabolic pathologies, including obesity, diabetes, cardiovascular disease, asthma, and cancer, cluster together to present the greatest…
Author(s): Fu S, Yalcin A, Lee GY, Li P, Fan J, Arruda AP, Pers BM, Yilmaz M, Eguchi K, Hotamisligil GS|Journal: Sci Transl Med|PMID:26084805| June 2015
The endoplasmic reticulum (ER) plays a critical role in protein, lipid, and glucose metabolism as well as cellular calcium signaling…
