A hormone complex of FABP4 and nucleoside kinases regulates islet function.

Author(s): Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Cedillo P, Achenbach P, Ziegler AG, Calay ES, Engin F, Hotamisligil GSJournal: NaturePMID: 34880500 December 2021
The liberation of energy stores from adipocytes is critical to support survival in times of energy deficit; however, uncontrolled or…

TMEM2 Modulates ER Stress in a Non-canonical Manner.

Author(s): Goncalves RLS, Hotamisligil GSJournal: Cell MetabPMID: 31801059 December 2019
Cells utilize multiple mechanisms to support endoplasmic reticulum (ER) function. The unfolded protein response, UPR, is engaged during proteotoxic challenges…

12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.

Author(s): Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Blüher M, Cypess AM, Kiebish MA, Spite M, Tseng YHJournal: Cell MetabPMID: 31353262 October 2019
Distinct oxygenases and their oxylipin products have been shown to participate in thermogenesis by mediating physiological adaptations required to sustain…