Publications

Cardiolipin deficiency in Barth syndrome is not associated with increased superoxide/H₂ O₂ production in heart and skeletal muscle mitochondria.

Author(s): Goncalves RLS, Schlame M, Bartelt A, Brand MD, Hotamisligil GS|Journal: FEBS Lett|PMID: 33112430| October 2020

Barth syndrome (BTHS) is a rare X-linked genetic disorder caused by mutations in the gene encoding the transacylase tafazzin and…

TMEM2 Modulates ER Stress in a Non-canonical Manner.

Author(s): Goncalves RLS, Hotamisligil GS|Journal: Cell Metab|PMID: 31801059| December 2019

Cells utilize multiple mechanisms to support endoplasmic reticulum (ER) function. The unfolded protein response, UPR, is engaged during proteotoxic challenges…

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.

Author(s): Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS|Journal: Nat Med|PMID: 29400713| March 2018

Adipocytes possess remarkable adaptive capacity to respond to nutrient excess, fasting or cold exposure, and they are thus an important…