Publications

Sympathetic tone dictates the impact of lipolysis on FABP4 secretion.

Author(s): Prentice KJ, Lee A, Cedillo P, Inouye KE, Ertunc ME, Riveros JK, Lee GY, Hotamisligil GS|Journal: J Lipid Res|PMID: 37172691| July 2023

Levels of circulating FABP4 protein are strongly associated with obesity and metabolic disease in both mice and humans, and secretion…

Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion.

Author(s): Inouye KE, Prentice KJ, Lee A, Wang ZB, Dominguez-Gonzalez C, Chen MX, Riveros JK, Burak MF, Lee GY, Hotamisligil GS|Journal: JCI Insight|PMID: 37279064| July 2023

Fatty acid binding protein 4 (FABP4) is a lipid chaperone secreted from adipocytes upon stimulation of lipolysis. Circulating FABP4 levels…

A hormone complex of FABP4 and nucleoside kinases regulates islet function.

Author(s): Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Cedillo P, Achenbach P, Ziegler AG, Calay ES, Engin F, Hotamisligil GS|Journal: Nature|PMID: 34880500| December 2021

The liberation of energy stores from adipocytes is critical to support survival in times of energy deficit; however, uncontrolled or…

Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses.

Author(s): Prentice KJ, Saksi J, Hotamisligil GS|Journal: J Lipid Res|PMID: 30705117| April 2019

Although counterregulatory hormones and mediators of the fight-or-flight responses are well defined at many levels, how energy stores per se…