Publications

Regulation of liver subcellular architecture controls metabolic homeostasis

Author(s): Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamisligil GS|Journal: Nature|PMID: 35264794| March 2022

Cells display complex intracellular organization by compartmentalization of metabolic processes into organelles, yet the resolution of these structures in the…

Aberrant Ca2+ signaling by IP3Rs in adipocytes links inflammation to metabolic dysregulation in obesity.

Author(s): Güney E, Arruda AP, Parlakgül G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS|Journal: Sci Signal|PMID: 34905386| December 2021

Chronic metabolic inflammation is a key feature of obesity, insulin resistance, and diabetes. Here, we showed that altered regulation of…

Defective STIM-mediated store operated Ca²⁺ entry in hepatocytes leads to metabolic dysfunction in obesity.

Author(s): Arruda AP, Pers BM, Parlakgül G, Güney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GS|Journal: Elife|PMID: 29243589| December 2017

Defective Ca handling is a key mechanism underlying hepatic endoplasmic reticulum (ER) dysfunction in obesity. ER Ca level is in…

Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity.

Author(s): Arruda AP, Pers BM, Parlakgül G, Güney E, Inouye K, Hotamisligil GS|Journal: Nat Med|PMID: 25419710| December 2014

Proper function of the endoplasmic reticulum (ER) and mitochondria is crucial for cellular homeostasis, and dysfunction at either site has…