Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

Author(s): Widenmaier SB, Snyder NA, Nguyen TB, Arduini A, Lee GY, Arruda AP, Saksi J, Bartelt A, Hotamisligil GSJournal: CellPMID: 29149604 November 2017

Cholesterol is a critical nutrient requiring tight constraint in the endoplasmic reticulum (ER) due to its uniquely challenging biophysical properties. While…

METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.

Author(s): Yang L., Calay ES, Fan J, Arduini A, Kunz RC, Gygi SP, Yalcin A, Fu S, Hotamisligil GSJournal: SciencePMID: 26228140 July 2015

The association between inflammation and endoplasmic reticulum (ER) stress has been observed in many diseases. However, if and how chronic…

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

Author(s): Nakamura T, Arduini A, Baccaro B, Furuhashi M, Hotamisligil GSJournal: DiabetesPMID: 24150608 February 2014

Obesity and metabolic diseases appear as clusters, often featuring high risk for insulin resistance and type 2 diabetes, and constitute…