A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity. Author(s): Nakamura T, Kunz RC, Zhang C, Kimura T, Yuan CL, Baccaro B, Namiki Y, Gygi SP, Hotamisligil GS|Journal: Cell Rep|PMID: 25843719| April 2015 Aberrant stress and inflammatory responses are key factors in the pathogenesis of obesity and metabolic dysfunction, and the double-stranded RNA-dependent…
Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice. Author(s): Nakamura T, Arduini A, Baccaro B, Furuhashi M, Hotamisligil GS|Journal: Diabetes|PMID: 24150608| February 2014 Obesity and metabolic diseases appear as clusters, often featuring high risk for insulin resistance and type 2 diabetes, and constitute…