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Sabri Ülker Center for Nutrient, Genetic, and Metabolic Research
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Aberrant islet unfolded protein response in type 2 diabetes.

Author(s): Engin F, Nguyen T, Yermalovich A, Hotamisligil GS|Journal: Sci Rep|PMID: 24514745| February 2014
The endoplasmic reticulum adapts to fluctuations in demand and copes with stress through an adaptive signaling cascade called the unfolded…

Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes.

Author(s): Engin F, Yermalovich A, Nguyen T, Hummasti S, Fu W, Eizirik DL, Mathis D, Hotamisligil GS|Journal: Sci Transl Med|PMID: 24225943| November 2013
Perturbations in endoplasmic reticulum (ER) homeostasis can evoke stress responses leading to aberrant glucose and lipid metabolism. ER dysfunction is…
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