Publications

Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes.

Author(s): Engin F, Yermalovich A, Nguyen T, Hummasti S, Fu W, Eizirik DL, Mathis D, Hotamisligil GS|Journal: Sci Transl Med|PMID: 24225943| November 2013

Perturbations in endoplasmic reticulum (ER) homeostasis can evoke stress responses leading to aberrant glucose and lipid metabolism. ER dysfunction is…

The role of adipocyte XBP1 in metabolic regulation during lactation.

Author(s): Gregor MF, Misch ES, Yang L., Hummasti S, Inouye KE, Lee AH, Bierie B, Hotamisligil GS|Journal: Cell Rep|PMID: 23623498| May 2013

The adipocyte is central to organismal metabolism and exhibits significant functional and morphological plasticity during its formation and lifespan. Remarkable…

Endoplasmic reticulum stress and inflammation in obesity and diabetes.

Author(s): Hummasti S, Hotamisligil GS|Journal: Circ Res|PMID: 20814028| September 2010

Obesity is a major problem worldwide that increases risk for a wide range of diseases, including diabetes and heart disease.…