Publications

The role of adipocyte XBP1 in metabolic regulation during lactation.

Author(s): Gregor MF, Misch ES, Yang L., Hummasti S, Inouye KE, Lee AH, Bierie B, Hotamisligil GS|Journal: Cell Rep|PMID: 23623498| May 2013

The adipocyte is central to organismal metabolism and exhibits significant functional and morphological plasticity during its formation and lifespan. Remarkable…

Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion.

Author(s): Lee AH, Heidtman K, Hotamisligil GS, Glimcher LH|Journal: Proc Natl Acad Sci U S A|PMID: 21555585| May 2011

As a key regulator of the unfolded protein response, the transcription factor XBP1 activates genes in protein secretory pathways and…

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

Author(s): Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS|Journal: Science|PMID: 15486293| October 2004

Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and…