Author(s): Wellen KE, Uysal KT, Wiesbrock S, Yang Q, Chen H, Hotamisligil GS|Journal: Endocrinology|PMID:14764635| May 2004
Thiazolidinediones (TZDs) are potent insulin-sensitizing compounds and high-affinity ligands for the transcription factor peroxisomal proliferator-activated receptor gamma. The mechanism through…
The metabolic syndrome is a cluster of metabolic and inflammatory abnormalities including obesity, insulin resistance, type 2 diabetes, hypertension, dyslipidemia,…
Author(s): Way JM, Gorgun CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR Jr, Willson TM, Kliewer SA, Hotamisligil GS|Journal: J Biol Chem|PMID:11373275| July 2001
Elevated levels of the hormone resistin, which is secreted by fat cells, are proposed to cause insulin resistance and to…
The adipocyte fatty-acid-binding protein, aP2, has an important role in regulating systemic insulin resistance and lipid metabolism. Here we demonstrate…
Author(s): Nisoli E, Briscini L, Giordano A, Tonello C, Wiesbrock SM, Uysal KT, Cinti S, Carruba MO, Hotamisligil GS|Journal: Proc Natl Acad Sci U S A|PMID:10884431| July 2000
Severe quantitative and qualitative brown adipocyte defects are common in obesity. To investigate whether aberrant expression of tumor necrosis factor…