Publications

Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways.

Author(s): Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD|Journal: Cell Metab|PMID: 21723501| July 2011

Through unknown mechanisms, insulin activates the sterol regulatory element-binding protein (SREBP1c) transcription factor to promote hepatic lipogenesis. We find that…

Nutrient sensing and inflammation in metabolic diseases.

Author(s): Hotamisligil GS, Erbay E|Journal: Nat Rev Immunol|PMID: 19029988| December 2008

The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic…

Adipocyte/macrophage fatty acid binding proteins in metabolic syndrome.

Author(s): Erbay E, Cao H, Hotamisligil GS|Journal: Curr Atheroscler Rep|PMID: 18241617| September 2007

The link between inflammation and the development of insulin resistance, type 2 diabetes, and atherosclerosis has been uncovered in the…

Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance.

Author(s): Tilg H, Hotamisligil GS|Journal: Gastroenterology|PMID: 16952562| September 2006

Neuronal PTP1B regulates body weight, adiposity and leptin action.

Author(s): Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB|Journal: Nat Med|PMID: 16845389| August 2006

Obesity is a major health problem and a risk factor for type 2 diabetes. Leptin, an adipocyte-secreted hormone, acts on…

Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.

Author(s): Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS|Journal: Cell Metab|PMID: 16054052| February 2005

Fatty acid binding proteins (FABPs) are cytosolic fatty acid chaperones whose biological role and mechanisms of action are not well…