Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity.

Author(s): Fu S, Yang L., Li P, Hofmann O, Dicker L, Hide W, Lin X, Watkins SM, Ivanov AR, Hotamisligil GSJournal: NaturePMID: 21532591 May 2011

The endoplasmic reticulum (ER) is the main site of protein and lipid synthesis, membrane biogenesis, xenobiotic detoxification and cellular calcium…

CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance.

Author(s): Chavey C, Lazennec G, Lagarrigue S, Clapé C, Iankova I, Teyssier J, Annicotte JS, Schmidt J, Mataki C, Yamamoto H, Sanches R, Guma A, Stich V, Vitkova M, Jardin-Watelet B, Renard E, Strieter R, Tuthill A, Hotamisligil GS, Vidal-Puig A, Zorzano A, Langin D, Fajas LJournal: Cell MetabPMID: 19356715 April 2009

We show here high levels of expression and secretion of the chemokine CXC ligand 5 (CXCL5) in the macrophage fraction…

Nutrient sensing and inflammation in metabolic diseases.

Author(s): Hotamisligil GS, Erbay EJournal: Nat Rev ImmunolPMID: 19029988 December 2008

The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic…

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.

Author(s): Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GSJournal: Mol CellPMID: 18342602 March 2008

Mammalian target of rapamycin, mTOR, is a major sensor of nutrient and energy availability in the cell and regulates a…

Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis.

Author(s): Wellen KE, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GSJournal: CellPMID: 17482547 May 2007

Metabolic and inflammatory pathways crosstalk at many levels, and, while required for homeostasis, interaction between these pathways can also lead…