Publications

Macrophage Mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-γ-regulated genes.

Author(s): Babaev VR, Runner RP, Fan D, Ding L, Zhang Y, Tao H, Erbay E, Gorgun CZ, Fazio S, Hotamisligil GS, Linton MF|Journal: Arterioscler Thromb Vasc Biol|PMID: 21474828| June 2011

The adipocyte/macrophage fatty acid-binding proteins aP2 (FABP4) and Mal1 (FABP5) are intracellular lipid chaperones that modulate systemic glucose metabolism, insulin…

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis.

Author(s): Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow ME, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS|Journal: Nat Med|PMID: 19966778| December 2009

Macrophages show endoplasmic reticulum (ER) stress when exposed to lipotoxic signals associated with atherosclerosis, although the pathophysiological importance and the…

Nutrient sensing and inflammation in metabolic diseases.

Author(s): Hotamisligil GS, Erbay E|Journal: Nat Rev Immunol|PMID: 19029988| December 2008

The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic…

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets.

Author(s): Furuhashi M, Hotamisligil GS|Journal: Nat Rev Drug Discov|PMID: 18511927| June 2008

Lipids are vital components of many biological processes and crucial in the pathogenesis of numerous common diseases, but the specific…