Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Author(s): Yang L., Li P, Fu S, Calay ES, Hotamisligil GS|Journal: Cell Metab|PMID: 20519119| June 2010 Autophagy is a homeostatic process involved in the bulk degradation of cytoplasmic components, including damaged organelles and proteins. In both…
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Author(s): Hotamisligil GS|Journal: Cell|PMID: 20303879| March 2010 The endoplasmic reticulum (ER) is the major site in the cell for protein folding and trafficking and is central to…
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Author(s): Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS|Journal: Cell|PMID: 20144759| February 2010 As chronic inflammation is a hallmark of obesity, pathways that integrate nutrient- and pathogen sensing pathways are of great interest…
CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Author(s): Chavey C, Lazennec G, Lagarrigue S, Clapé C, Iankova I, Teyssier J, Annicotte JS, Schmidt J, Mataki C, Yamamoto H, Sanches R, Guma A, Stich V, Vitkova M, Jardin-Watelet B, Renard E, Strieter R, Tuthill A, Hotamisligil GS, Vidal-Puig A, Zorzano A, Langin D, Fajas L|Journal: Cell Metab|PMID: 19356715| April 2009 We show here high levels of expression and secretion of the chemokine CXC ligand 5 (CXCL5) in the macrophage fraction…
Inflammation and endoplasmic reticulum stress in obesity and diabetes. Author(s): Hotamisligil GS|Journal: Int J Obes (Lond)|PMID: 19136991| December 2008 Obesity is associated with chronic low-grade inflammation. Inflammatory signals interfere with insulin action and disrupt metabolic homeostasis. The c-Jun N-terminal…
Nutrient sensing and inflammation in metabolic diseases. Author(s): Hotamisligil GS, Erbay E|Journal: Nat Rev Immunol|PMID: 19029988| December 2008 The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic…
