Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

Author(s): Furuhashi M, Tuncman G, Gorgun CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GSJournal: NaturePMID: 17554340 June 2007

Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Studies in aP2-deficient…

Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.

Author(s): Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Brüning JCJournal: Cell MetabPMID: 16581002 April 2006

Inflammatory processes play an important role in the pathogenesis of vascular diseases, and insulin-resistant diabetes mellitus type 2 represents an…

The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis.

Author(s): Makowski L, Hotamisligil GSJournal: Curr Opin LipidolPMID: 16148539 October 2005

The global prevalence of obesity is increasing epidemically. Obesity causes an array of health problems, reduces life expectancy, and costs…

The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities.

Author(s): Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GSJournal: J Biol ChemPMID: 15684432 April 2005

Fatty acid-binding proteins are cytosolic fatty acid chaperones, and the adipocyte isoform, aP2, plays an important role in obesity and…

Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.

Author(s): Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GSJournal: CirculationPMID: 15353487 September 2004

The adipocyte fatty acid-binding protein (FABP) aP2 is expressed by adipocytes and macrophages and modulates insulin resistance, glucose and lipid…

Fatty acid binding proteins–the evolutionary crossroads of inflammatory and metabolic responses.

Author(s): Makowski L, Hotamisligil GSJournal: J NutrPMID: 15333743 September 2004

Fatty acid binding proteins (FABPs) are members of a highly conserved family of proteins with the task of protecting a…

Role of the fatty acid binding protein mal1 in obesity and insulin resistance.

Author(s): Maeda K, Uysal KT, Makowski L, Gorgun CZ, Atsumi G, Parker RA, Brüning J, Hertzel AV, Bernlohr DA, Hotamisligil GSJournal: DiabetesPMID: 12540600 February 2003

The metabolic syndrome is a cluster of metabolic and inflammatory abnormalities including obesity, insulin resistance, type 2 diabetes, hypertension, dyslipidemia,…

Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia.

Author(s): Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GSJournal: Arterioscler Thromb Vasc BiolPMID: 12377750 October 2002

The adipocyte fatty acid-binding protein, aP2, has important effects on insulin resistance, lipid metabolism, and atherosclerosis. Its expression in macrophages…

Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.

Author(s): Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MFJournal: Nat MedPMID: 11385507 June 2001

The adipocyte fatty-acid-binding protein, aP2, has an important role in regulating systemic insulin resistance and lipid metabolism. Here we demonstrate…