Publications

Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2.

Author(s): Rolph MS, Young TR, Shum BO, Gorgun CZ, Schmitz-Peiffer C, Ramshaw IA, Hotamisligil GS, Mackay CR|Journal: J Immunol|PMID: 17114450| December 2006

The fatty acid-binding protein (FABP) family consists of a number of conserved cytoplasmic proteins with roles in intracellular lipid transport,…

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.

Author(s): Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamisligil GS|Journal: Science|PMID: 16931765| August 2006

Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type 2 diabetes. Here, we provide evidence…

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.

Author(s): Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS|Journal: Proc Natl Acad Sci U S A|PMID: 16818881| July 2006

The c-Jun N-terminal kinases (JNKs) are key regulators of inflammation and interfere with insulin action in cultured cells and whole…

A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease.

Author(s): Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS|Journal: Proc Natl Acad Sci U S A|PMID: 16641093| May 2006

Obesity and the associated pathologies including dyslipidemia, insulin resistance, type 2 diabetes, and cardiovascular disease constitute a major threat to…