Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease.

Author(s): Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GSJournal: Proc Natl Acad Sci U S APMID: 16641093 May 2006

Obesity and the associated pathologies including dyslipidemia, insulin resistance, type 2 diabetes, and cardiovascular disease constitute a major threat to…

Association between dietary factors and plasma adiponectin concentrations in men.

Author(s): Pischon T, Girman CJ, Rifai N, Hotamisligil GS, Rimm EBJournal: Am J Clin NutrPMID: 15817852 April 2005

Adiponectin, an adipocyte-derived peptide, improves insulin sensitivity, has antiinflammatory and antiatherogenic effects, and is associated with a lower risk of…

Plasma adiponectin levels and risk of myocardial infarction in men.

Author(s): Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EBJournal: JAMAPMID: 15082700 April 2004

Adiponectin, a recently discovered adipocyte-derived peptide, is involved in the regulation of insulin sensitivity and lipid oxidation and, purportedly, in…

Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers.

Author(s): Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Rimm EBJournal: Obes ResPMID: 12972675 September 2003

This study investigated the relationship between physical activity and the obesity-related inflammatory markers C-reactive protein, interleukin-6, and soluble tumor necrosis…

Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women.

Author(s): Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Willett WC, Rimm EBJournal: CirculationPMID: 12821543 July 2003

Polyunsaturated fatty acid intake favorably affects chronic inflammatory-related diseases such as cardiovascular disease; however, high intake of n-6 fatty acids…

Adiponectin: stability in plasma over 36 hours and within-person variation over 1 year.

Author(s): Pischon T, Hotamisligil GS, Rimm EBJournal: Clin ChemPMID: 12651819 April 2003

Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men.

Author(s): Chu NF, Spiegelman D, Hotamisligil GS, Rifai N, Stampfer M, Rimm EBJournal: AtherosclerosisPMID: 11472752 August 2001

Obesity is related to cardiovascular disease (CVD) morbidity and mortality, however, the mechanisms for the development of obesity-induced CVD risk…

Plasma leptin concentrations and four-year weight gain among US men.

Author(s): Chu NF, Spiegelman D, Yu J, Rifai N, Hotamisligil GS, Rimm EBJournal: Int J Obes Relat Metab DisordPMID: 11319631 March 2001

Leptin, a primarily adipose tissue-derived protein product of the obesity (ob) gene, is an important regulator of energy metabolism. The…

Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men.

Author(s): Chu NF, Stampfer MJ, Spiegelman D, Rifai N, Hotamisligil GS, Rimm EBJournal: Int J Obes Relat Metab DisordPMID: 11244465 January 2001

Leptin, the product of the obesity (ob) gene, is a multi-functional polypeptide that is important in energy metabolism, which is…

Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US men.

Author(s): Chu NF, Spiegelman D, Rifai N, Hotamisligil GS, Rimm EBJournal: Int J Obes Relat Metab DisordPMID: 11033975 September 2000

Leptin, an adipocyte-derived protein product of the obesity (ob) gene, is a multifunctional polypeptide associated with the development of obesity-related…