Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance.

Author(s): Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BMJournal: DiabetesPMID: 9032102 March 1997

Previous studies have shown that tumor necrosis factor (TNF)-alpha production from adipose tissue is elevated in rodent and human obesity…

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance.

Author(s): Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BMJournal: SciencePMID: 8571133 February 1996

Tumor necrosis factor-alpha (TNF-alpha) is an important mediator of insulin resistance in obesity and diabetes through its ability to decrease…

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Author(s): Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BMJournal: J Clin InvestPMID: 7738205 May 1995

Obesity is frequently associated with insulin resistance and abnormal glucose homeostasis. Recent studies in animal models have indicated that TNF-alpha…

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

Author(s): Hotamisligil GS, Budavari A, Murray D, Spiegelman BMJournal: J Clin InvestPMID: 7523453 October 1994

Insulin resistance is an important metabolic abnormality often associated with infections, cancer, obesity, and especially non-insulin-dependent diabetes mellitus (NIDDM). We…

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

Author(s): Hotamisligil GS, Murray DL, Choy LN, Spiegelman BMJournal: Proc Natl Acad Sci U S APMID: 8197147 May 1994

Insulin resistance is a common problem associated with infections and cancer and, most importantly, is the central component of non-insulin-dependent…

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.

Author(s): Hotamisligil GS, Shargill NS, Spiegelman BMJournal: SciencePMID: 7678183 January 1993

Tumor necrosis factor-alpha (TNF-alpha) has been shown to have certain catabolic effects on fat cells and whole animals. An induction…