Publications

Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses.

Author(s): Prentice KJ, Saksi J, Hotamisligil GS|Journal: J Lipid Res|PMID: 30705117| April 2019

Although counterregulatory hormones and mediators of the fight-or-flight responses are well defined at many levels, how energy stores per se…

Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins.

Author(s): Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamisligil GS|Journal: Cell Rep|PMID: 29020626| October 2017

Deterioration of metabolic health is a hallmark of aging and generally assumed to be detrimental to longevity. Exposure to a…

Foundations of Immunometabolism and Implications for Metabolic Health and Disease.

Author(s): Hotamisligil GS|Journal: Immunity|PMID: 28930657| September 2017

Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of…

Inflammation, metaflammation and immunometabolic disorders.

Author(s): Hotamisligil GS|Journal: Nature|PMID: 28179656| February 2017

Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental…

Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment.

Author(s): Ertunc ME, Hotamisligil GS|Journal: J Lipid Res|PMID: 27330055| December 2016

Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids, and triglycerides. These molecules represent a highly…

De Novo Lipogenesis Products and Endogenous Lipokines.

Author(s): Yilmaz M, Claiborn KC, Hotamisligil GS|Journal: Diabetes|PMID: 27288005| July 2016

Recent studies have shown that in addition to their traditionally recognized functions as building blocks, energy stores, or hazardous intermediates,…

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes.

Author(s): Arruda AP, Hotamisligil GS|Journal: Cell Metab|PMID: 26190652| September 2015

A number of chronic metabolic pathologies, including obesity, diabetes, cardiovascular disease, asthma, and cancer, cluster together to present the greatest…