Publications

TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis.

Author(s): Liu L, Inouye KE, Allman WR, Coleman AS, Siddiqui S, Hotamisligil GS, Akkoyunlu MJournal: DiabetesPMID: 29871859 August 2018

Transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) is a receptor for the TNF superfamily cytokines, B cell-activating…

Defective STIM-mediated store operated Ca²⁺ entry in hepatocytes leads to metabolic dysfunction in obesity.

Author(s): Arruda AP, Pers BM, Parlakgül G, Güney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GSJournal: ElifePMID: 29243589 December 2017

Defective Ca handling is a key mechanism underlying hepatic endoplasmic reticulum (ER) dysfunction in obesity. ER Ca level is in…

Foundations of Immunometabolism and Implications for Metabolic Health and Disease.

Author(s): Hotamisligil GSJournal: ImmunityPMID: 28930657 September 2017

Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of…

Inflammation, metaflammation and immunometabolic disorders.

Author(s): Hotamisligil GSJournal: NaturePMID: 28179656 February 2017

Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental…

Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment.

Author(s): Ertunc ME, Hotamisligil GSJournal: J Lipid ResPMID: 27330055 December 2016

Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids, and triglycerides. These molecules represent a highly…

De Novo Lipogenesis Products and Endogenous Lipokines.

Author(s): Yilmaz M, Claiborn KC, Hotamisligil GSJournal: DiabetesPMID: 27288005 July 2016

Recent studies have shown that in addition to their traditionally recognized functions as building blocks, energy stores, or hazardous intermediates,…

Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.

Author(s): Babaev VR, Yeung M, Erbay E, Ding L, Zhang Y, May JM, Fazio S, Hotamisligil GS, Linton MFJournal: Arterioscler Thromb Vasc BiolPMID: 27102962 June 2016

The c-Jun NH2-terminal kinases (JNK) are regulated by a wide variety of cellular stresses and have been implicated in apoptotic…