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Publications

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TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis.

Author(s): Liu L, Inouye KE, Allman WR, Coleman AS, Siddiqui S, Hotamisligil GS, Akkoyunlu M|Journal: Diabetes|PMID: 29871859| August 2018
Transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) is a receptor for the TNF superfamily cytokines, B cell-activating…

Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity.

Author(s): Arruda AP, Pers BM, Parlakgül G, Güney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GS|Journal: Elife|PMID: 29243589| December 2017
Defective Ca handling is a key mechanism underlying hepatic endoplasmic reticulum (ER) dysfunction in obesity. ER Ca level is in…

Foundations of Immunometabolism and Implications for Metabolic Health and Disease.

Author(s): Hotamisligil GS|Journal: Immunity|PMID: 28930657| September 2017
Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of…

Inflammation, metaflammation and immunometabolic disorders.

Author(s): Hotamisligil GS|Journal: Nature|PMID: 28179656| February 2017
Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental…

Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment.

Author(s): Ertunc ME, Hotamisligil GS|Journal: J Lipid Res|PMID: 27330055| December 2016
Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids, and triglycerides. These molecules represent a highly…

De Novo Lipogenesis Products and Endogenous Lipokines.

Author(s): Yilmaz M, Claiborn KC, Hotamisligil GS|Journal: Diabetes|PMID: 27288005| July 2016
Recent studies have shown that in addition to their traditionally recognized functions as building blocks, energy stores, or hazardous intermediates,…

Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.

Author(s): Babaev VR, Yeung M, Erbay E, Ding L, Zhang Y, May JM, Fazio S, Hotamisligil GS, Linton MF|Journal: Arterioscler Thromb Vasc Biol|PMID: 27102962| June 2016
The c-Jun NH2-terminal kinases (JNK) are regulated by a wide variety of cellular stresses and have been implicated in apoptotic…

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes.

Author(s): Arruda AP, Hotamisligil GS|Journal: Cell Metab|PMID: 26190652| September 2015
A number of chronic metabolic pathologies, including obesity, diabetes, cardiovascular disease, asthma, and cancer, cluster together to present the greatest…

METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.

Author(s): Yang L., Calay ES, Fan J, Arduini A, Kunz RC, Gygi SP, Yalcin A, Fu S, Hotamisligil GS|Journal: Science|PMID: 26228140| July 2015
The association between inflammation and endoplasmic reticulum (ER) stress has been observed in many diseases. However, if and how chronic…

Potential role for snoRNAs in PKR activation during metabolic stress.

Author(s): Youssef OA, Safran SA, Nakamura T, Nix DA, Hotamisligil GS, Bass BL|Journal: Proc Natl Acad Sci U S A|PMID: 25848059| April 2015
Protein kinase RNA-activated (PKR) has long been known to be activated by viral double-stranded RNA (dsRNA) as part of the…

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