Publications

Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins.

Author(s): Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamisligil GS|Journal: Cell Rep|PMID: 29020626| October 2017

Deterioration of metabolic health is a hallmark of aging and generally assumed to be detrimental to longevity. Exposure to a…

Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis.

Author(s): ten Freyhaus H, Calay ES, Yalcin A, Vallerie SN, Yang L., Calay ZZ, Saatcioglu F, Hotamisligil GS|Journal: Cell Metab|PMID: 22704678| July 2012

The six-transmembrane protein Stamp2 plays an important role in metabolically triggered inflammation and insulin action. We report that Stamp2 is…

Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways.

Author(s): Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD|Journal: Cell Metab|PMID: 21723501| July 2011

Through unknown mechanisms, insulin activates the sterol regulatory element-binding protein (SREBP1c) transcription factor to promote hepatic lipogenesis. We find that…

Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.

Author(s): Yang L., Li P, Fu S, Calay ES, Hotamisligil GS|Journal: Cell Metab|PMID: 20519119| June 2010

Autophagy is a homeostatic process involved in the bulk degradation of cytoplasmic components, including damaged organelles and proteins. In both…