Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes.

Author(s): Arruda AP, Hotamisligil GSJournal: Cell MetabPMID: 26190652 September 2015

A number of chronic metabolic pathologies, including obesity, diabetes, cardiovascular disease, asthma, and cancer, cluster together to present the greatest…

METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.

Author(s): Yang L., Calay ES, Fan J, Arduini A, Kunz RC, Gygi SP, Yalcin A, Fu S, Hotamisligil GSJournal: SciencePMID: 26228140 July 2015

The association between inflammation and endoplasmic reticulum (ER) stress has been observed in many diseases. However, if and how chronic…

A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity.

Author(s): Nakamura T, Kunz RC, Zhang C, Kimura T, Yuan CL, Baccaro B, Namiki Y, Gygi SP, Hotamisligil GSJournal: Cell RepPMID: 25843719 April 2015

Aberrant stress and inflammatory responses are key factors in the pathogenesis of obesity and metabolic dysfunction, and the double-stranded RNA-dependent…

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

Author(s): Nakamura T, Arduini A, Baccaro B, Furuhashi M, Hotamisligil GSJournal: DiabetesPMID: 24150608 February 2014

Obesity and metabolic diseases appear as clusters, often featuring high risk for insulin resistance and type 2 diabetes, and constitute…

The role of adipocyte XBP1 in metabolic regulation during lactation.

Author(s): Gregor MF, Misch ES, Yang L., Hummasti S, Inouye KE, Lee AH, Bierie B, Hotamisligil GSJournal: Cell RepPMID: 23623498 May 2013

The adipocyte is central to organismal metabolism and exhibits significant functional and morphological plasticity during its formation and lifespan. Remarkable…

Novel role of PKR in inflammasome activation and HMGB1 release.

Author(s): Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJJournal: NaturePMID: 22801494 August 2012

The inflammasome regulates the release of caspase activation-dependent cytokines, including interleukin (IL)-1β, IL-18 and high-mobility group box 1 (HMGB1). By…

Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress.

Author(s): Oh RS, Pan WC, Yalcin A, Zhang H, Guilarte TR, Hotamisligil GS, Christiani DC, Lu QJournal: J Biol ChemPMID: 22215663 February 2012

Exposure to the toxic metalloid arsenic is associated with diabetes and cancer and causes proteotoxicity and endoplasmic reticulum (ER) stress…

CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance.

Author(s): Chavey C, Lazennec G, Lagarrigue S, Clapé C, Iankova I, Teyssier J, Annicotte JS, Schmidt J, Mataki C, Yamamoto H, Sanches R, Guma A, Stich V, Vitkova M, Jardin-Watelet B, Renard E, Strieter R, Tuthill A, Hotamisligil GS, Vidal-Puig A, Zorzano A, Langin D, Fajas LJournal: Cell MetabPMID: 19356715 April 2009

We show here high levels of expression and secretion of the chemokine CXC ligand 5 (CXCL5) in the macrophage fraction…

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.

Author(s): Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GSJournal: Mol CellPMID: 18342602 March 2008

Mammalian target of rapamycin, mTOR, is a major sensor of nutrient and energy availability in the cell and regulates a…