Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

Coordinated regulation of protein synthesis and degradation by mTORC1.

Author(s): Zhang Y, Nicholatos J, Dreier JR, Ricoult SJ, Widenmaier SB, Hotamisligil GS, Kwiatkowski DJ, Manning BDJournal: NaturePMID: 25043031 September 2014

Eukaryotic cells coordinately control anabolic and catabolic processes to maintain cell and tissue homeostasis. Mechanistic target of rapamycin complex 1…

Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways.

Author(s): Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BDJournal: Cell MetabPMID: 21723501 July 2011

Through unknown mechanisms, insulin activates the sterol regulatory element-binding protein (SREBP1c) transcription factor to promote hepatic lipogenesis. We find that…

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.

Author(s): Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GSJournal: Mol CellPMID: 18342602 March 2008

Mammalian target of rapamycin, mTOR, is a major sensor of nutrient and energy availability in the cell and regulates a…