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Publications

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A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.

Author(s): Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH|Journal: Nature|PMID: 24153306| October 2013
Food intake increases the activity of hepatic de novo lipogenesis, which mediates the conversion of glucose to fats for storage…

Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways.

Author(s): Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD|Journal: Cell Metab|PMID: 21723501| July 2011
Through unknown mechanisms, insulin activates the sterol regulatory element-binding protein (SREBP1c) transcription factor to promote hepatic lipogenesis. We find that…
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