Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production.

Author(s): Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GSJournal: Cell MetabPMID: 23663740 May 2013

Proper control of hepatic glucose production is central to whole-body glucose homeostasis, and its disruption plays a major role in…

Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study.

Author(s): Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GSJournal: Ann Intern MedPMID: 21173413 December 2010

Palmitoleic acid (cis-16:1n-7), which is produced by endogenous fat synthesis, has been linked to both beneficial and deleterious metabolic effects,…

Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes.

Author(s): Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GSJournal: Am J Clin NutrPMID: 20943795 December 2010

Animal experiments suggest that circulating palmitoleic acid (cis-16:1n-7) from adipocyte de novo fatty acid synthesis may directly regulate insulin resistance…

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis.

Author(s): Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GSJournal: CellPMID: 20144759 February 2010

As chronic inflammation is a hallmark of obesity, pathways that integrate nutrient- and pathogen sensing pathways are of great interest…

Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.

Author(s): Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GSJournal: CellPMID: 18805087 September 2008

Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin action and glucose metabolism. Utilizing quantitative lipidomic…

Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice.

Author(s): Furuhashi M, Fucho R, Gorgun CZ, Tuncman G, Cao H, Hotamisligil GSJournal: J Clin InvestPMID: 18551191 July 2008

Adipose tissue inflammation is a characteristic of obesity. However, the mechanisms that regulate this inflammatory response and link adipose inflammation…