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Sabri Ülker Center for Nutrient, Genetic, and Metabolic Research
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Publications

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The role of adipocyte XBP1 in metabolic regulation during lactation.

Author(s): Gregor MF, Misch ES, Yang L., Hummasti S, Inouye KE, Lee AH, Bierie B, Hotamisligil GS|Journal: Cell Rep|PMID: 23623498| May 2013
The adipocyte is central to organismal metabolism and exhibits significant functional and morphological plasticity during its formation and lifespan. Remarkable…

Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production.

Author(s): Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS|Journal: Cell Metab|PMID: 23663740| May 2013
Proper control of hepatic glucose production is central to whole-body glucose homeostasis, and its disruption plays a major role in…

Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting.

Author(s): Fu S, Fan J, Blanco J, Gimenez-Cassina A, Danial NN, Watkins SM, Hotamisligil GS|Journal: PLoS Genet|PMID: 22927828| August 2012
Obesity-associated metabolic complications are generally considered to emerge from abnormalities in carbohydrate and lipid metabolism, whereas the status of protein…

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity.

Author(s): Fu S, Yang L., Li P, Hofmann O, Dicker L, Hide W, Lin X, Watkins SM, Ivanov AR, Hotamisligil GS|Journal: Nature|PMID: 21532591| May 2011
The endoplasmic reticulum (ER) is the main site of protein and lipid synthesis, membrane biogenesis, xenobiotic detoxification and cellular calcium…

Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

Author(s): Kars M, Yang L., Gregor MF, Mohammed BS, Pietka TA, Finck BN, Patterson BW, Horton JD, Mittendorfer B, Hotamisligil GS, Klein S|Journal: Diabetes|PMID: 20522594| August 2010
Insulin resistance is commonly associated with obesity. Studies conducted in obese mouse models found that endoplasmic reticulum (ER) stress contributes…

Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.

Author(s): Yang L., Li P, Fu S, Calay ES, Hotamisligil GS|Journal: Cell Metab|PMID: 20519119| June 2010
Autophagy is a homeostatic process involved in the bulk degradation of cytoplasmic components, including damaged organelles and proteins. In both…

Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss.

Author(s): Gregor MF, Yang L., Fabbrini E, Mohammed BS, Eagon JC, Hotamisligil GS, Klein S|Journal: Diabetes|PMID: 19066313| March 2009
Obesity is associated with insulin resistance and type 2 diabetes, although the mechanisms linking these pathologies remain undetermined. Recent studies…

The transcription factor GATA2 regulates differentiation of brown adipocytes.

Author(s): Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GS|Journal: EMBO Rep|PMID: 16082385| September 2005
Brown adipose tissue (BAT) is a specialized mammalian tissue and a site of adaptive thermogenesis. Although the metabolic functions of…

Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.

Author(s): Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS|Journal: Circulation|PMID: 15353487| September 2004
The adipocyte fatty acid-binding protein (FABP) aP2 is expressed by adipocytes and macrophages and modulates insulin resistance, glucose and lipid…
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