Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

The role of adipocyte XBP1 in metabolic regulation during lactation.

Author(s): Gregor MF, Misch ES, Yang L., Hummasti S, Inouye KE, Lee AH, Bierie B, Hotamisligil GSJournal: Cell RepPMID: 23623498 May 2013

The adipocyte is central to organismal metabolism and exhibits significant functional and morphological plasticity during its formation and lifespan. Remarkable…

Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production.

Author(s): Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GSJournal: Cell MetabPMID: 23663740 May 2013

Proper control of hepatic glucose production is central to whole-body glucose homeostasis, and its disruption plays a major role in…

Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting.

Author(s): Fu S, Fan J, Blanco J, Gimenez-Cassina A, Danial NN, Watkins SM, Hotamisligil GSJournal: PLoS GenetPMID: 22927828 August 2012

Obesity-associated metabolic complications are generally considered to emerge from abnormalities in carbohydrate and lipid metabolism, whereas the status of protein…

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity.

Author(s): Fu S, Yang L., Li P, Hofmann O, Dicker L, Hide W, Lin X, Watkins SM, Ivanov AR, Hotamisligil GSJournal: NaturePMID: 21532591 May 2011

The endoplasmic reticulum (ER) is the main site of protein and lipid synthesis, membrane biogenesis, xenobiotic detoxification and cellular calcium…

Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

Author(s): Kars M, Yang L., Gregor MF, Mohammed BS, Pietka TA, Finck BN, Patterson BW, Horton JD, Mittendorfer B, Hotamisligil GS, Klein SJournal: DiabetesPMID: 20522594 August 2010

Insulin resistance is commonly associated with obesity. Studies conducted in obese mouse models found that endoplasmic reticulum (ER) stress contributes…

Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.

Author(s): Yang L., Li P, Fu S, Calay ES, Hotamisligil GSJournal: Cell MetabPMID: 20519119 June 2010

Autophagy is a homeostatic process involved in the bulk degradation of cytoplasmic components, including damaged organelles and proteins. In both…

Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss.

Author(s): Gregor MF, Yang L., Fabbrini E, Mohammed BS, Eagon JC, Hotamisligil GS, Klein SJournal: DiabetesPMID: 19066313 March 2009

Obesity is associated with insulin resistance and type 2 diabetes, although the mechanisms linking these pathologies remain undetermined. Recent studies…

The transcription factor GATA2 regulates differentiation of brown adipocytes.

Author(s): Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GSJournal: EMBO RepPMID: 16082385 September 2005

Brown adipose tissue (BAT) is a specialized mammalian tissue and a site of adaptive thermogenesis. Although the metabolic functions of…

Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.

Author(s): Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GSJournal: CirculationPMID: 15353487 September 2004

The adipocyte fatty acid-binding protein (FABP) aP2 is expressed by adipocytes and macrophages and modulates insulin resistance, glucose and lipid…