Publications

Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress.

Author(s): Oh RS, Pan WC, Yalcin A, Zhang H, Guilarte TR, Hotamisligil GS, Christiani DC, Lu Q|Journal: J Biol Chem|PMID: 22215663| February 2012

Exposure to the toxic metalloid arsenic is associated with diabetes and cancer and causes proteotoxicity and endoplasmic reticulum (ER) stress…

The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities.

Author(s): Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS|Journal: J Biol Chem|PMID: 15684432| April 2005

Fatty acid-binding proteins are cytosolic fatty acid chaperones, and the adipocyte isoform, aP2, plays an important role in obesity and…

SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice.

Author(s): Emanuelli B, Peraldi P, Filloux C, Chavey C, Freidinger K, Hilton DJ, Hotamisligil GS, Van Obberghen E|Journal: J Biol Chem|PMID: 11604392| December 2001

SOCS (suppressor of cytokine signaling) proteins are inhibitors of cytokine signaling involved in negative feedback loops. We have recently shown…

Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists.

Author(s): Way JM, Gorgun CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR Jr, Willson TM, Kliewer SA, Hotamisligil GS|Journal: J Biol Chem|PMID: 11373275| July 2001

Elevated levels of the hormone resistin, which is secreted by fat cells, are proposed to cause insulin resistance and to…

Transmembrane tumor necrosis factor (TNF)-alpha inhibits adipocyte differentiation by selectively activating TNF receptor 1.

Author(s): Xu H, Sethi JK, Hotamisligil GS|Journal: J Biol Chem|PMID: 10473584| September 1999

Tumor necrosis factor alpha (TNFalpha) is a potent cytokine with multiple biological activities and exists in two forms as follows:…

Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase.

Author(s): Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM|Journal: J Biol Chem|PMID: 8662983| May 1996

Tumor necrosis factor (TNF)-alpha plays a central role in the state of insulin resistance associated with obesity. It has previously…

Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes.

Author(s): Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P|Journal: J Biol Chem|PMID: 8463205| April 1993