Author(s): Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GS|Journal: Cell Metab|PMID:33340456| December 2020
Endoplasmic reticulum stress (ERS) has a pathophysiological role in obesity-associated insulin resistance. Yet, the coordinated tissue response to ERS remains…
Author(s): Goncalves RLS, Hotamisligil GS|Journal: Cell Metab|PMID:31801059| December 2019
Cells utilize multiple mechanisms to support endoplasmic reticulum (ER) function. The unfolded protein response, UPR, is engaged during proteotoxic challenges…
Author(s): Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Blüher M, Cypess AM, Kiebish MA, Spite M, Tseng YH|Journal: Cell Metab|PMID:31353262| October 2019
Distinct oxygenases and their oxylipin products have been shown to participate in thermogenesis by mediating physiological adaptations required to sustain…
Author(s): Parlakgül G, Hotamisligil GS|Journal: Cell Metab|PMID:28591628| June 2017
The specific immunological components linking metabolic stresses to liver inflammation and systemic metabolic pathologies in obesity are not entirely known.…
Author(s): Arruda AP, Hotamisligil GS|Journal: Cell Metab|PMID:26190652| September 2015
A number of chronic metabolic pathologies, including obesity, diabetes, cardiovascular disease, asthma, and cancer, cluster together to present the greatest…
Author(s): Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS|Journal: Cell Metab|PMID:23663740| May 2013
Proper control of hepatic glucose production is central to whole-body glucose homeostasis, and its disruption plays a major role in…
