Publications

TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis.

Author(s): Liu L, Inouye KE, Allman WR, Coleman AS, Siddiqui S, Hotamisligil GS, Akkoyunlu M|Journal: Diabetes|PMID: 29871859| August 2018

Transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) is a receptor for the TNF superfamily cytokines, B cell-activating…

De Novo Lipogenesis Products and Endogenous Lipokines.

Author(s): Yilmaz M, Claiborn KC, Hotamisligil GS|Journal: Diabetes|PMID: 27288005| July 2016

Recent studies have shown that in addition to their traditionally recognized functions as building blocks, energy stores, or hazardous intermediates,…

FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues.

Author(s): Garin-Shkolnik T, Rudich A, Hotamisligil GS, Rubinstein M|Journal: Diabetes|PMID: 24319114| March 2014

Fatty acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed primarily in adipocytes…

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

Author(s): Nakamura T, Arduini A, Baccaro B, Furuhashi M, Hotamisligil GS|Journal: Diabetes|PMID: 24150608| February 2014

Obesity and metabolic diseases appear as clusters, often featuring high risk for insulin resistance and type 2 diabetes, and constitute…

Impact of ER protein homeostasis on metabolism.

Author(s): Yalcin A, Hotamisligil GS|Journal: Diabetes|PMID: 23431011| March 2013

Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

Author(s): Kars M, Yang L., Gregor MF, Mohammed BS, Pietka TA, Finck BN, Patterson BW, Horton JD, Mittendorfer B, Hotamisligil GS, Klein S|Journal: Diabetes|PMID: 20522594| August 2010

Insulin resistance is commonly associated with obesity. Studies conducted in obese mouse models found that endoplasmic reticulum (ER) stress contributes…

Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss.

Author(s): Gregor MF, Yang L., Fabbrini E, Mohammed BS, Eagon JC, Hotamisligil GS, Klein S|Journal: Diabetes|PMID: 19066313| March 2009

Obesity is associated with insulin resistance and type 2 diabetes, although the mechanisms linking these pathologies remain undetermined. Recent studies…

Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women.

Author(s): Song Y, Manson JE, Tinker L, Rifai N, Cook NR, Hu FB, Hotamisligil GS, Ridker PM, Rodriguez BL, Margolis KL, Oberman A, Liu S|Journal: Diabetes|PMID: 17389327| July 2007

Elevated circulating levels of soluble adhesion molecules as markers of endothelial dysfunction have been related to insulin resistance and its…

Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice.

Author(s): Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamisligil GS|Journal: Diabetes|PMID: 16804058| July 2006

Fatty acid-binding proteins (FABPs) are cytosolic fatty acid chaperones that play a critical role in systemic regulation of lipid and…

Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes.

Author(s): Hotamisligil GS|Journal: Diabetes|PMID: 16306344| December 2005

Metabolic and immune systems are the most fundamental requirements for survival, and many metabolic and immune response pathways or nutrient-…